Senior Research Assistant position - MD Anderson Cancer Center
Dear all, This post is to bring your attention to a job opportunity for a Senior Research Assistant position at the University of Texas, MD Anderson Cancer Center (in Houston, Texas, USA). MD Anderson Cancer Center is the number one cancer center in the United States and a center of excellence for both oncology treatment and research. This is an opportunity to join a dedicated team of researchers that are working together to develop new cancer therapeutics to positively impact the lives of our patients. We are looking for a highly motivated individual with experience in molecular biology and protein production to work within our structural biology team to support research projects across the MD Anderson research community and the drug discovery pipeline of the Institute for Applied Cancer Science. The research that stems from the proteins produced has a direct impact on the lives of our patients. Salaries are competitive and based on the level of experience of the applicant. We are looking for applicants with a Bachelors or Masters degree in Biochemistry, Biotechnology, Pharmacology or a related subject. Previous experience working in a research lab environment is desired. The ideal candidate will have previous molecular biology or protein purification experience. For more information and to submit a job application please refer to the job posting… https://mdanderson.referrals.selectminds.com/jobs/sr-research-asst-genomic-m... We look forward to reviewing your application. Please use the above link to submit your application, CV and cover letter. Best wishes, Paul Leonard The information contained in this e-mail message may be privileged, confidential, and/or protected from disclosure. This e-mail message may contain protected health information (PHI); dissemination of PHI should comply with applicable federal and state laws. If you are not the intended recipient, or an authorized representative of the intended recipient, any further review, disclosure, use, dissemination, distribution, or copying of this message or any attachment (or the information contained therein) is strictly prohibited. If you think that you have received this e-mail message in error, please notify the sender by return e-mail and delete all references to it and its contents from your systems.
Dear All— I have a question about the options in a series of Autobuild runs I am attempting. I have a structure that has 8 chains in the asymmetric unit, and one of the chains has very poor density. I ran phenix.refine using a model that lacked this chain, and now I want to run Autobuild to attempt to build in that chain. The issue I am running into is that I want Autobuild to only build into the density where there is no model, but not modify or build in density that is occupied by the model I give it. What are the options I should select to attempt this? Thank you for your help! David Korasick Postdoctoral Fellow Tanner Lab University of Missouri-Columbia, Department of Biochemistry [email protected]
Hi David,
Unfortunately there isn't a way yet in autobuild to completely fix part of the model and try to build another part from scratch. However one of the steps in autobuild is "build_outside = True" which blanks out the density wherever there is a model and builds into the remainder. This is kind of what you want to do, but it is combined with other building steps.
Another option is to use phenix.cut_out_density using a dummy model for the region that is not built to mark it. Then you can run phenix.map_to_model on the cut out map to build just that part. Let me know if that works for you!
All the best,
Tom T
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From: [email protected]
participants (3)
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Korasick, David A.
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Leonard,Paul
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Terwilliger, Thomas Charles