Dear all, This is a reminder that Diamond Light Source is accepting proposals for its XChem fragment screening facility, for the allocation period April to September 2020. The deadline is Wednesday 2nd October at 5pm (2 weeks from now). Details on how to apply are here - we're oversubscribed, so please follow the instructions! https://www.diamond.ac.uk/Instruments/Mx/Fragment-Screening/Applying-for-XCh... XChem is a platform for high-throughput crystal-based fragment screening, operational since 2015. We provide fragment libraries (or you can bring your own) and the pipeline entails: rapid crystal soaking with an Echo acoustic liquid handler; high-throughput harvesting of hundreds of pre-soaked crystals using a Shifter; fully unattended data collection using dedicated beamtime on I04-1 beamline; and automated data integration along with tools for ligand detection (PanDDA) and streamlined model building (XChemExplorer). Since April 2019, we offer both standard and Block Allocation Group (BAG) access. Standard access accommodates both Tier 1 and Tier 2 proposals, for exploratory and ready-to-go projects respectively. Since this summer, the FragLites library from Newcastle university (J. Med. Chem.20196273741-3752) is also available for users. More information is on the XChem website: https://www.diamond.ac.uk/Instruments/Mx/Fragment-Screeninghttps://www.diamond.ac.uk/Instruments/Mx/Fragment-Screening/Methods-for-Frag... https://www.diamond.ac.uk/Instruments/Mx/Fragment-Screening/Methods-for-Frag...https://www.diamond.ac.uk/Instruments/Mx/Fragment-Screening/Fragment-Librari... https://www.diamond.ac.uk/Instruments/Mx/Fragment-Screening/Fragment-Librari... For more questions, please ask Alice (copied) or myself. We are looking forward to collaborating with you! The XChem team.