[phenixbb] Are sigma cutoffs for R-free reflections cheating?

Pavel Afonine PAfonine at lbl.gov
Fri Dec 4 22:13:36 PST 2009

Hi Ed,

> You are essentially asking for proof that all the experimental data must
> be included while fitting theoretical model to it. 

No, of course. I was just wondering how better (and what is "better" in 
this case) the refinement results will be if one includes the negative 
(zero) reflections into the process of refinement, and did anyone 
clearly demonstrate it. That's all I asked.
Again, I hardly believe that you will notice the difference in 
refinement outcome (refiened model) if phenix.refine removes a few zero 
reflections that are in your PDB file. But I might be wrong and so wrote 
my previous question.


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