[phenixbb] bulk solvent mask question

[Laurie Betts]

I notice that during refinement of a MR solution for a protein (search model
is 100% homologous to target), a very large ligand-binding cavity (as much
as 20 A wide in some parts) in my protein gives weak positive difference
density for a ligand soaked into the crystals, unless I turn off bulk
solvent modeling.  Then the fo-fc difference density is quite strong (2.6
Angstrom data).  I think this is due to part of the cavity being included in
bulk solvent?

Can I edit the mask easily, or flag parts of the protein as NOT exposed to
solvent?

Thanks

Laurie Betts
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