[phenixbb] MR-Rosetta server?

Terwilliger, Thomas C terwilliger at lanl.gov
Tue Apr 2 11:32:45 PDT 2013

Hi Mark,

I don't know of any server for mr_rosetta at present, but the Robetta server can do the homology modeling part:


It is not too difficult to install rosetta; when I do it I just cut and paste and edit the instructions that are on the phenix mr_rosetta web page at https://www.phenix-online.org/documentation/mr_rosetta.htm#anch35 (Installing Rosetta for use with mr_rosetta).

All the best,
Tom T

From: phenixbb-bounces at phenix-online.org [phenixbb-bounces at phenix-online.org] on behalf of Mark J van Raaij [mjvanraaij at cnb.csic.es]
Sent: Tuesday, April 02, 2013 12:00 PM
To: phenixbb at phenix-online.org
Subject: [phenixbb] MR-Rosetta server?

Dear All,

for a recent dataset, I would like to try MR-Rosetta, as normal MR didn't work (not surprising perhaps, as the closest model is from NMR and with only about 20% sequence identity). Even though I don't think there is much chance of success, I would like to try MR-Rosetta anyway, although without having to install Rosetta if possible.
Is there a server that would take care of the whole process? I.e. take the input mtz and the hopefully homologous structure supplied by me, and run Rosetta followed by MR in Phenix?

In its defect, is there an online server that does the Rosetta part of MR-Rosetta, that would give a Rosetta-improved output model for putting into MR by Phenix, which I already have installed?

Some side-ways related questions:
- is it feasible to install Rosetta under MacOSX for a not very computer-literate user?
- Phenix seems to slow down my MacPro a lot, even if I use just one of the 8 processors - is 4 Gb of RAM too little?

Sorry for the rather rambling mail...



Mark J van Raaij
Lab 20B
Dpto de Estructura de Macromoleculas
Centro Nacional de Biotecnologia - CSIC
c/Darwin 3
E-28049 Madrid, Spain
tel. (+34) 91 585 4616

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