[phenixbb] SIGF in refinement

Pavel Afonine pafonine at lbl.gov
Mon Apr 29 07:41:19 PDT 2013

Hi Anastasia,

experimental "sigmas" are not used in ML (and MLHL) targets. They are 
used in LS target.
This means that if you refine against EM map (which I understand you do 
by converting map into {Fobs, HL} and thus use MLHL target) then 
"sigmas" are not used.

Reference to papers that describe ML target (as well as others) used in 
phenix.refine can be found... (guess where?) - right, in phenix.refine 


All the best,

On 4/29/13 6:51 AM, Aksyuk, Anastasia (NIH/NIAMS) [F] wrote:
> Hi,
> I was wondering how SigFobs values are used in phenix refinement and how important those are. I am asking in view of P1 space group with low redundancy or even cryo-EM map based Fobs. Maybe you can point me to a useful reference on likelihood targets. I feel lost in those that I have.
> Thanks,
> --Anastasia

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