[phenixbb] on real_space_refine

[Pavel Afonine]

> After fitting a PDB into a 3.5-5 A resolution EM map by 
> phenix.real_space_refine, should I still need to do a reciprocal space 
> refine?

Why?

> For crystallography, the reciprocal space is in fact not purely 
> imaginary,

Indeed!

> But for the EM data refinement, what is the reciprocal space refine?

If you imagine cryo-EM data to be in reciprocal space you can do 
reciprocal space refinement then. This may work given you know why you 
do this.

Pavel

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