[phenixbb] Scientist-I (Structural Biology) - Frederick National Lab for Cancer Research

Dhirendra K Simanshu simanshu at gmail.com
Wed May 13 07:22:02 PDT 2015

Dear colleagues,

We have an opening for a Scientist-I (Structural Biology)
 here in Frederick, MD. If not interested, please forward this email to
those who might be.

To apply for this
 and for further details, including a job description and qualifications,
please click on the link below:

Thank you

The Scientist I will work in support of the FNL/NCI RAS Initiative. One of
the major objectives of the RAS initiative at the Frederick National Lab
for Cancer Research (FNLCR) is to conduct structural analysis of KRAS
mutants and biologically relevant KRAS activator/effector complexes in
support of drug discovery efforts. The Scientist I will be responsible for:
1) carrying out structural studies on KRAS-effector complexes through the
entire protein crystallographic process, including construct design,
protein purification, biochemical and biophysical characterization,
crystallization, X-ray data collection, structure determination and
analysis, 2) working closely with an integrated team of protein scientists
in the Protein Expression Laboratory (PEL) at the FNLCR, 3) participating
in experimental design and to independently conduct experiments in a
priority-driven environment, 4) completing projects independently and as
part of a team, and providing timely updates of the project progress to
their supervisor both informally and by formal report writing, and 5)
generating high-quality peer-reviewed publications. Work may involve the
use of potentially hazardous chemical, biological, or radiological
materials or may be located in areas where such materials are used. May
require the use of personal protective equipment and adherence to strict
safety protocols.


   - PhD in structural biology, protein biochemistry, crystallography, or
   in a related discipline from an accredited college or university
   appropriate to biomedical research, or eight (8) years’ experience in lieu
   of degree
   - Foreign degrees must be evaluated for U.S. Equivalency
   - In addition to the educational requirements the candidate will need
   proven ability in all aspects of protein crystallography from construct
   design through structure determination and interpretation
   - Extensive experience in crystallization of protein-ligand and
   protein-protein complexes
   - Experience collecting data at synchrotron beamline and solving ab
   initio structures
   - Expertise in commonly used crystallography software packages
   - Proficiency in protein biochemical and biophysical characterization
   - Record of publications in peer-reviewed journals


   - Relevant postdoctoral experience in a structural biology laboratory.
   - Experience working with small GTPases, RAS-related activator/effector
   proteins, or membrane-associated complexes.
   - Knowledge of molecular dynamics simulations and protein-ligand docking.

*To apply*, click here:
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