[phenixbb] Registration open: Future of Fragments symposium - Diamond, 28/29 Nov 2016
Frank von Delft
frank.vondelft at sgc.ox.ac.uk
Thu Sep 22 23:56:05 PDT 2016
Registration is now open for the Future of Fragments symposium on 28/29
November at Diamond Light Source, UK.
Places will be tight, so register early to give us time to gauge whether
we must adapt plans.
Crystal-based fragment screening of novel protein targets linked to
disease has truly come of age: Diamond's XChem facility has been
operating a regular user program since 2015, with other synchrotrons
soon to follow suit. A progression of user projects have confirmed the
power of this approach to discover both diverse chemotypes and
unexpected mechanisms of action, especially allosteric binders.
At the same time, the continued success in unearthing a rich array of
fragment hits has now decisively shifted the bottleneck onto the
question of how to translate hits into high potency leads. This
challenge has highlighted the need for efficient and scalable
methodologies in the areas of library design, label-free assays,
computational compound design and the synthesis of complex lead molecules.
This symposium aims to highlight the opportunities that must be explored
if routine fragment screening is to turn into routine lead discovery.
The event will bring together speakers from diverse disciplines to help
define the methodology, focus and goals for fragment screening in the
The four sessions will cover: screening methodology; computational
methods; new synthetic methods; and automated chemistry.
-------------- next part --------------
An HTML attachment was scrubbed...
More information about the phenixbb