[phenixbb] Refining alternate conformation of duplex DNA

Pavel Afonine pafonine at lbl.gov
Wed Jun 19 09:43:24 PDT 2019


Hi Abhishek,

I'm confident you can do it, and it is explained to some degree here:

"13 typical occupancy refinement scenarios and available options in 
phenix.refine"
http://phenix-online.org/newsletter/

In the GUI it should be straightforward, if not please come back to us 
with *specific* questions.

Pavel


On 6/18/19 23:48, ABHISHEK SUMAN wrote:
> Hello All,
>
> I am solving a X-ray crystal structure of protein-DNA complex at 2.3 
> Angs. In my structure, it seems like the the duplex DNA is bound in 
> two different conformations, and both the conformations are occupied 
> in same density. I wish to know how to refine the alternative 
> conformations of the DNA duplex in Phenix. In am using Phenix GUI.
>
> Thanks
> Abhishek
>
> *______________________________________________
> *
>
> *Abhishek Suman*
>
> /Research Scholar, PhD/
>
> C/o, Dr. Rajakumara Eerappa
>
> Macromolecular Structural Biology Group
>
> Department of Biotechnology
>
> R# 517,315, Academic Block - A
>
> Indian Institute of Technology Hyderabad
>
> Kandi 502 285 Sangareddy
>
> Telangana INDIA
>
> Contact: +91 91002 74548 (O)
>
>          +91 80843 11898 (R)
>
> Email: abhisheks.iith at gmail.com <mailto:abhisheks.iith at gmail.com>
>
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