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Dear PhenixBB,
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<div class="">We have a crystal form that xtriage flags as having strong translational pseudo symmetry (Patterson peak 57% the height of the origin peak, p-value = 3E-5).
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<div class="">The space group is P21212. We can solve the structure with MR and refine to R=0.233 and R-free =0.276 at 2.25 Angstrom resolution. The maps look very good, but do not suggest major additional modeling that could be done to improve the structure
and lower the R-factors. I know that one expects the R-factors from refinement to be higher when TPS is present, but my question is how high is too high? Has anyone done a study that shows the expectations for R-factors when TPS is present? </div>
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<div class="">Thanks,</div>
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<div class="">Jack </div>
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John J. Tanner<br class="">
Interim Chair, Department of Biochemistry </div>
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Professor of Biochemistry and Chemistry</div>
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<span style="text-align: -webkit-auto;" class="">Department of Biochemistry</span></div>
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University of Missouri-Columbia<br class="">
117 Schweitzer Hall</div>
<div class="">503 S College Avenue<br class="">
Columbia, MO 65211<br class="">
Phone: 573-884-1280</div>
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Fax: 573-882-5635<br class="">
Email: <a href="mailto:tannerjj@missouri.edu" class="">tannerjj@missouri.edu</a><br class="">
<a href="http://faculty.missouri.edu/~tannerjj/tannergroup/tanner.html" class="">http://faculty.missouri.edu/~tannerjj/tannergroup/tanner.html</a></div>
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Lab: Schlundt Annex rooms 3,6,9, 203B, 203C</div>
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Office: Schlundt Annex 203A</div>
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