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<font size="2"><span style="-webkit-text-size-adjust: auto;"><font face="Arial" class="">The Hoelz laboratory at the California Institute of Technology seeks to recruit two outstanding postdoctoral scientists in structural cell biology. Our laboratory focuses
on the structure-function relationships of the nuclear pore complex and associated nucleocytoplasmic transport machinery.</font><span style="background-color: rgb(255, 255, 255);"></span></span><span style="-webkit-text-size-adjust: auto; background-color: rgb(255, 255, 255);"></span></font>
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<div style="-webkit-text-size-adjust: auto;"><span style="font-family: Arial;"><font size="2">This position requires a recent Ph.D. degree in biochemistry/biophysics with a strong background in biochemistry, x-ray crystallography, and/or cryo-electron microscopy/tomography.
The successful applicant should be a highly motivated individual with good organizational, communication, and interpersonal skills, who is able to carry out a structure determination project from the development of recombinant protein expression systems to
structure refinement.</font></span></div>
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<div style="-webkit-text-size-adjust: auto;"><span style="font-family: Arial;"><font size="2">The laboratory is well-funded and equipped with modern biophysical instrumentation. Importantly, Caltech has an exceptional infrastructure for structural biology,
including access to a high intensity, completely automated, state-of-the-art crystallography beamline at the Stanford Synchrotron Radiation Lightsource (SSRL), as well as an excellent cryo-electron microscopy facility with access to FEI Arctica and Titan Krios
microscopes equipped with Gatan K3 cameras. </font></span></div>
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<div style="-webkit-text-size-adjust: auto;"><span style="font-family: Arial;"><font size="2">The positions are available immediately and funded for 3+ years. Depending on performance, the position can be extended for additional years.</font></span></div>
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<div style="-webkit-text-size-adjust: auto;"><font size="2"><span style="font-family: Arial;">To apply, please send your CV, a statement of research interests, and the names and contact information of at least two references to André Hoelz (</span><a href="mailto:hoelz@caltech.edu" class="" style="font-family: Arial;">hoelz@caltech.edu</a><span style="font-family: Arial;">).</span></font></div>
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<div style="-webkit-text-size-adjust: auto;"><span style="font-family: Arial;"><font size="2">Selected Publications</font></span></div>
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<div style="-webkit-text-size-adjust: auto;"><font size="2"><span style="font-family: Arial;">Lin, D. H., </span><b class="" style="font-family: Arial;">Hoelz, A.*</b><span style="font-family: Arial;"> (2019). The structure of the nuclear pore complex (an update). </span><b class="" style="font-family: Arial;">Annu.
Rev. Biochem</b><span style="font-family: Arial;">. </span><i class="" style="font-family: Arial;">88</i><span style="font-family: Arial;">, 725-783. </span></font></div>
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<div style="-webkit-text-size-adjust: auto;"><font size="2"><span style="font-family: Arial;">Lin, D. H., Correia, A.C., Cai, S.W., Huber, F.M. Jette, C.A., </span><b class="" style="font-family: Arial;">Hoelz, A.*</b><span style="font-family: Arial;"> (2018).
Structural and functional analysis of mRNA export regulation by the nuclear pore complex. </span><b class="" style="font-family: Arial;">Nat. Commun.</b><span style="font-family: Arial;">, 2319.</span></font></div>
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<div style="-webkit-text-size-adjust: auto;"><font size="2"><span style="font-family: Arial;">Huber, F., </span><b class="" style="font-family: Arial;">Hoelz, A.,*</b><span style="font-family: Arial;"> (2017). Molecular basis for protection of ribosomal protein
L4 from cellular degradation, </span><b class="" style="font-family: Arial;">Nat. Commun. </b><i class="" style="font-family: Arial;">8</i><span style="font-family: Arial;">, 14354. </span><br>
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<div style="-webkit-text-size-adjust: auto;"><font size="2">Lin, D.,<sup class="" style="font-family: Arial;">#</sup><span style="font-family: Arial;"> Stuwe, T.,</span><sup class="" style="font-family: Arial;">#</sup><span style="font-family: Arial;"> Schilbach,
S., Rundlet, E.J., Perriches, T., Mobbs, G., Fan, Y., Thierbach, K., Huber, F.M., Collins, L.N., Davenport, A.M., Jeon, Y.E., </span><b class="" style="font-family: Arial;">Hoelz, A.*</b><span style="font-family: Arial;"> (2016). Architecture of the symmetric
core of the nuclear pore, </span><b class="" style="font-family: Arial;">Science</b><span style="font-family: Arial;"> </span><i class="" style="font-family: Arial;">352, </i><span style="font-family: Arial;">aaf1015. [Cover]</span></font></div>
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<div style="-webkit-text-size-adjust: auto;"><font size="2"><span style="font-family: Arial;">Stuwe, T.,</span><sup class="" style="font-family: Arial;">#</sup><span style="font-family: Arial;"> Bley, C.J.,</span><sup class="" style="font-family: Arial;">#</sup><span style="font-family: Arial;"> Thierbach,
K.,</span><sup class="" style="font-family: Arial;">#</sup><span style="font-family: Arial;"> Petrovic, S.,</span><sup class="" style="font-family: Arial;">#</sup><span style="font-family: Arial;"> Schilbach, S., Mayo, D.J., Perriches, T., Rundlet, E.J., Jeon,
Y.J., Collins, L.N., Huber, F.M., Lin, D.H., Paduch, M., Koide, A., Lu, V., Fischer, J., Hurt, E., Koide, S., Kossiakoff, A., </span><b class="" style="font-family: Arial;">Hoelz, A.*</b><span style="font-family: Arial;"> (2015). Architecture of the fungal
nuclear pore inner ring complex, </span><b class="" style="font-family: Arial;">Science</b><span style="font-family: Arial;"> </span><i class="" style="font-family: Arial;">350</i><span style="font-family: Arial;">, 56-64.</span></font></div>
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<div style="-webkit-text-size-adjust: auto;"><font size="2"><span style="font-family: Arial;">Stuwe, T.,</span><sup class="" style="font-family: Arial;">#</sup><span style="font-family: Arial;"> Correia, A.,</span><sup class="" style="font-family: Arial;">#</sup><span style="font-family: Arial;"> Lin,
D. H., Paduch, M., Lu, V. T., Kossiakoff, A. A., </span><b class="" style="font-family: Arial;">Hoelz, A.</b><span style="font-family: Arial;">* (2015). Architecture of the nuclear pore complex coat.</span><b class="" style="font-family: Arial;"> Science </b><i class="" style="font-family: Arial;">347</i><span style="font-family: Arial;">,
1148-1152. </span></font></div>
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<div style="-webkit-text-size-adjust: auto;"><font size="2"><b class="" style="font-family: Arial;">Hoelz, A.</b><span style="font-family: Arial;">,* Debler, E.W., Blobel, G. (2011). Structure of the Nuclear Pore Complex, </span><b class="" style="font-family: Arial;">Annu.
Rev. Biochem.</b><span style="font-family: Arial;"> </span><i class="" style="font-family: Arial;">80</i><span style="font-family: Arial;">,</span><i class="" style="font-family: Arial;"> 613-643.</i></font></div>
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<div style="-webkit-text-size-adjust: auto;"><i class="" style="font-family: Arial;"><font size="2"><span style="font-style: normal; font-family: Helvetica; background-color: rgb(255, 255, 255);">---</span><br class="" style="font-style: normal; font-family: Helvetica;">
<span style="font-style: normal; font-family: Helvetica; background-color: rgb(255, 255, 255);">André Hoelz, Ph.D.</span><br class="" style="font-style: normal; font-family: Helvetica;">
<span style="font-style: normal; font-family: Helvetica; background-color: rgb(255, 255, 255);">Faculty Scholar, Howard Hughes Medical Institute</span><br class="" style="font-style: normal; font-family: Helvetica;">
<span style="font-style: normal; font-family: Helvetica; background-color: rgb(255, 255, 255);">Investigator, Heritage Medical Research Institute</span><br class="" style="font-style: normal; font-family: Helvetica;">
<span style="font-style: normal; font-family: Helvetica; background-color: rgb(255, 255, 255);">Professor of Chemistry and Biochemistry</span><br class="" style="font-style: normal; font-family: Helvetica;">
<span style="font-style: normal; font-family: Helvetica; background-color: rgb(255, 255, 255);">Division of Chemistry and Chemical Engineering</span><br class="" style="font-style: normal; font-family: Helvetica;">
<span style="font-style: normal; font-family: Helvetica; background-color: rgb(255, 255, 255);">California Institute of Technology</span><br class="" style="font-style: normal; font-family: Helvetica;">
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