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<p class="MsoNormal">Thank you for sharing the following PhD opportunity with interested students! Best wishes, Flora<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><b>PhD fellowship in Structural Biology of Metalloenzymes at NC State & Oak Ridge national Laboratory<o:p></o:p></b></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p style="margin:0in;background:white"><span style="color:black">A Ph. D. research fellowship (up to 5 years) in enzyme chemistry is available with Dr. Flora Meilleur. The position is joint between North Carolina State University, the Ph. D. granting institution
where the Ph. D. candidate will complete the program core coursework, and Oak Ridge National Laboratory, where research activities will be performed.<o:p></o:p></span></p>
<p style="margin:0in;background:white"><span style="color:black"><o:p> </o:p></span></p>
<p style="margin:0in;background:white;box-sizing: border-box;margin:2rem;font-variant-ligatures: normal;font-variant-caps: normal;orphans: 2;text-align:start;widows: 2;-webkit-text-stroke-width: 0px;text-decoration-thickness: initial;text-decoration-style: initial;text-decoration-color: initial;word-spacing:0px">
<span style="color:black">The project will focus on lytic polysaccharide monooxygenase, a class of copper containing metalloenzymes involved in biomass oxidation. High resolution X-ray and neutron crystallography will be used primarily to study the enzymatic
mechanism. The project will involve collaborations to include spectroscopic and biophysical methods as well as computational approaches.
<o:p></o:p></span></p>
<p style="margin:0in;background:white"><span style="color:black"><o:p> </o:p></span></p>
<p style="margin:0in;background:white"><span style="color:black">Key publications on the topic include (complete list
<a href="https://scholar.google.com/citations?user=i0aLPhYAAAAJ&hl=en">here</a>):
<o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="color:black">Schr�der G.C., O’Dell W.B., Webb S.P., Agarwal P.K., and Meilleur F. (2021) Capture of activated dioxygen intermediates at the copper-active site of a lytic polysaccharide monooxygenase.
ChemRxiv. <a href="https://chemrxiv.org/engage/chemrxiv/article-details/61b3cdd8689c875d6adea959">
10.26434/chemrxiv-2021-n4c1x</a><o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><strong><span style="font-family:"Calibri",sans-serif;color:black;background:white;font-weight:normal">O’Dell W. B</span></strong><strong><span style="font-family:"Calibri",sans-serif;color:black;background:white">.</span></strong><span style="color:black;background:white">,
Aggarwal P.,<b> </b><strong><span style="font-family:"Calibri",sans-serif;font-weight:normal">Meilleur F.</span></strong> (2017) Oxygen Activation at the Active Site of a Fungal Lytic Polysaccharide Monooxygenase. <em><span style="font-family:"Calibri",sans-serif"><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340418/"><span style="font-style:normal">Angew.
Chem. Int. Ed. 56:767-770</span></a></span></em></span><span style="color:black"><o:p></o:p></span></p>
<p style="margin:0in;background:white"><span style="color:black"><o:p> </o:p></span></p>
<p style="margin:0in;background:white"><span style="color:black">The candidate should hold a degree in chemistry or biochemistry. Prior experience in molecular biology, protein expression, or protein purification is an advantage.<o:p></o:p></span></p>
<p style="margin:0in;background:white"><span style="color:black"><o:p> </o:p></span></p>
<p style="margin:0in;background:white;box-sizing: border-box;margin:2rem;font-variant-ligatures: normal;font-variant-caps: normal;orphans: 2;text-align:start;widows: 2;-webkit-text-stroke-width: 0px;text-decoration-thickness: initial;text-decoration-style: initial;text-decoration-color: initial;word-spacing:0px">
<span style="color:black">The position is available now and applications are welcome until the position is filled. Interested candidates must email a detailed CV, a letter of motivation and the name of three scientists for reference to
<a href="mailto:fmeille@ncsu.edu?subject=Application%20to%20NC%20State%20/%20ORNL%20PhD%20Fellowship">
Flora Meilleur</a> <em><span style="font-family:"Calibri",sans-serif">prior</span></em> to applying to the Graduate Program in Biochemistry at NC State.
<o:p></o:p></span></p>
<p style="margin:0in;background:white"><span style="color:black"><o:p> </o:p></span></p>
<p style="margin:0in;background:white"><span style="color:black">For further information about the position, interested candidates can contact
<a href="mailto:fmeille@ncsu.edu?subject=Questions%20about%20NC%20State/ORNL%20PhD%20Fellowship">
Flora Meilleur</a>.<o:p></o:p></span></p>
<p style="margin:0in;background:white"><span style="color:black">Further information about the NC State Biochemistry graduate program
<a href="https://cals.ncsu.edu/molecular-and-structural-biochemistry/">here</a>.<o:p></o:p></span></p>
<p style="margin:0in;background:white"><span style="color:black">Further information about the neutron facilities at Oak Ridge National Laboratory
<a href="https://neutrons.ornl.gov/">here</a>. <o:p></o:p></span></p>
<p class="MsoNormal"><o:p> </o:p></p>
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