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<p class="MsoNormal"><span style="font-size:11.0pt">As many of you know, the 2022 ACA meeting will be held in Portland, OR on July 29 to August 2. I would like to draw your attention to the session on fragment-based drug discovery and invite you to submit an
abstract for an oral presentation. We welcome contributions from students as well as PIs. The Abstract deadline is April 15.
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<p class="MsoNormal"><span style="font-size:11.0pt"><a href="https://www.acameeting.com/">https://www.acameeting.com/</a><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:11.0pt">Session details:<o:p></o:p></span></p>
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<p class="MsoNormal"><b><span style="font-size:11.0pt">3.2.2 Fragment Based Drug Discovery</span></b><span style="font-size:11.0pt"><br>
8/1/2022 @ 2:00:00 PM - 5:00:00 PM<br>
Sponsoring SIG(s): Industrial<br>
Co-Sponsoring SIG(s): BioMac<br>
Session Chair(s): Matt Clifton, Jack Tanner <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Fragment Based Drug Discovery (FBDD) utilizes small molecule compounds to help identify starting points in the drug discovery process. This process allowed for the discovery of lead compounds for difficult
protein targets with small/shallow pockets or protein-protein interactions. In contrast to other screening techniques such as High-Throughput Screening (HTS) or DNA-encoded Libraries (DEL), FBDD utilizes small libraries of molecules (< 2000) with molecular
weights less than ~200 Da. FBDD has been key in the development of multiple approved drugs and dozens of other drugs in clinical trials. This session will focus on the biophysical and structural techniques used in FBDD to identify initial starting points,
optimization by fragment growing/linking, and the route to lead optimization.<o:p></o:p></span></p>
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<p class="MsoNormal" style="background:white"><span style="font-size:11.5pt;font-family:Helvetica;color:black">John J. Tanner </span><span style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-size:11.5pt;font-family:Helvetica;color:black">Professor of Biochemistry and Chemistry</span><span style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-size:11.5pt;font-family:Helvetica;color:black">Associate Chair of Biochemistry</span><span style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-size:11.5pt;font-family:Helvetica;color:black">Department of Biochemistry</span><span style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-size:11.5pt;font-family:Helvetica;color:black">University of Missouri<br>
117 Schweitzer Hall</span><span style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-size:11.5pt;font-family:Helvetica;color:black">503 S College Avenue<br>
Columbia, MO 65211<br>
Phone: 573-884-1280</span><span style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-size:11.5pt;font-family:Helvetica;color:black"><a href="mailto:tannerjj@missouri.edu" target="_blank">Email: tannerjj@missouri.edu</a><br>
<a href="https://cafnrfaculty.missouri.edu/tannerlab/">https://cafnrfaculty.missouri.edu/tannerlab/</a></span><span style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-size:11.5pt;font-family:Helvetica;color:black">Lab: Schlundt Annex rooms 3,6,9, 203B, 203C</span><span style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.5pt;font-family:Helvetica;color:black;background:white">Office: Schlundt Annex 203A</span><span style="font-size:11.0pt"><o:p></o:p></span></p>
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