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<p class="MsoNormal"><span lang="EN-US">Hi developers,<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">I'm having difficulty minimizing ribosome structures using real_space_refine. The structures are mostly fine (I think) and there are no sever close-contacts. But it seems to happen in particular with waters and/or hydrogens
present. See below for an example error message. <o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">Searching the mailing list archive, I found an old thread on the same topic where Pavel explained that this can happen when the weights are set improperly.
<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><a href="https://phenix-online.org/pipermail/phenixbb/2017-November/023588.html">https://phenix-online.org/pipermail/phenixbb/2017-November/023588.html</a><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">I suspect my problems are related to the ad hoc method of setting weights does not work well for a large structure with 150,000+ atoms. When I check the log file, the weight estimation looks like this:<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal">XYZ refinement<o:p></o:p></p>
<p class="MsoNormal">**************<o:p></o:p></p>
<p class="MsoNormal">Weight determination summary:<o:p></o:p></p>
<p class="MsoNormal"> number of chunks: 2038<o:p></o:p></p>
<p class="MsoNormal"> random chunks:<o:p></o:p></p>
<p class="MsoNormal"> chunk 1215 optimal weight: 50.0000<o:p></o:p></p>
<p class="MsoNormal"> chunk 784 optimal weight: 5.9990<o:p></o:p></p>
<p class="MsoNormal"> chunk 1173 optimal weight: 50.0000<o:p></o:p></p>
<p class="MsoNormal"> chunk 591 optimal weight: 30.0000<o:p></o:p></p>
<p class="MsoNormal"> chunk 385 optimal weight: 50.0000<o:p></o:p></p>
<p class="MsoNormal"> chunk 380 optimal weight: 2.9990<o:p></o:p></p>
<p class="MsoNormal"> chunk 1248 optimal weight: 50.0000<o:p></o:p></p>
<p class="MsoNormal"> chunk 1338 optimal weight: 50.0000<o:p></o:p></p>
<p class="MsoNormal"> chunk 971 optimal weight: 50.0000<o:p></o:p></p>
<p class="MsoNormal"> chunk 183 optimal weight: 50.0000<o:p></o:p></p>
<p class="MsoNormal"> chunk 1543 optimal weight: 50.0000<o:p></o:p></p>
<p class="MsoNormal"> overall best weight: 27.7996<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><span lang="EN-US">So there seems to be a large discrepancy for the optimal weight for different chunks. Out of a 10-macro cycle run (crashed on the last cycle), the overall best weight varied between 3.7 and 34, which I suspect contributes
to the unstable minimization procedure.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"> overall best weight: 33.9998<o:p></o:p></p>
<p class="MsoNormal"> overall best weight: 20.5996<o:p></o:p></p>
<p class="MsoNormal"> overall best weight: 5.0186<o:p></o:p></p>
<p class="MsoNormal"> overall best weight: 4.6388<o:p></o:p></p>
<p class="MsoNormal"> overall best weight: 3.7586<o:p></o:p></p>
<p class="MsoNormal"> overall best weight: 34.1998<o:p></o:p></p>
<p class="MsoNormal"> overall best weight: 27.7996<o:p></o:p></p>
<p class="MsoNormal"> overall best weight: 18.1996<o:p></o:p></p>
<p class="MsoNormal"> overall best weight: 9.1992<o:p></o:p></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">Do you think a constant weight could be a solution to this problem? Is it possible to set it manually? Which of the weights are set using the heuristic method? Are there different weights for e.g. bonded restraints and
"extra" metal bond restraints? There are some references to weights in the .eff file and
</span>nonbonded_weight<span lang="EN-US"> seems to be an interesting option with a default value of 100.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">Regards,<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">Daniel<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">Example run that explodes:<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="p1"><span class="s1">phenix.real_space_refine resolution=</span><span class="s1"><span lang="EN-US">2</span></span><span class="s1"> run=minimization_global nproc=4 output.prefix=</span><span class="s1"><span lang="EN-US">phe</span></span><span class="s1">
output.suffix=_min ignore_symmetry_conflicts=True</span><span class="apple-converted-space">
</span><span class="s1">macro_cycles=10 ligands.cif elbow.edits coot-42.pdb </span>
<span class="s1"><span lang="EN-US">map</span></span><span class="s1">.mrc<o:p></o:p></span></p>
<p class="p1"><o:p> </o:p></p>
<p class="p1"><span class="s1">Traceback (most recent call last):</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">File "/Applications/phenix-1.20.1-4487/build/../modules/phenix/phenix/command_line/real_space_refine.py", line 8, in <module></span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">run_program(real_space_refine.Program)</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">File "/Applications/phenix-1.20.1-4487/modules/cctbx_project/iotbx/cli_parser.py", line 79, in run_program</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">task.run()</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">File "/Applications/phenix-1.20.1-4487/modules/phenix/phenix/programs/real_space_refine.py", line 207, in run</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">log
</span><span class="apple-converted-space"> </span><span class="s1">= self.logger)</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">File "/Applications/phenix-1.20.1-4487/modules/phenix/phenix/refinement/macro_cycle_real_space.py", line 297, in __init__</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">self.caller(self.refine_xyz)</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">File "/Applications/phenix-1.20.1-4487/modules/phenix/phenix/refinement/macro_cycle_real_space.py", line 312, in caller</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">func()</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">File "/Applications/phenix-1.20.1-4487/modules/phenix/phenix/refinement/macro_cycle_real_space.py", line 653, in refine_xyz</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">self.minimization_no_ncs()</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">File "/Applications/phenix-1.20.1-4487/modules/phenix/phenix/refinement/macro_cycle_real_space.py", line 716, in minimization_no_ncs</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">log
</span><span class="apple-converted-space"> </span><span class="s1">= self.log)</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">File "/Applications/phenix-1.20.1-4487/modules/cctbx_project/mmtbx/refinement/real_space/individual_sites.py", line 51, in __init__</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">gradients_method</span><span class="apple-converted-space">
</span><span class="s1">= gradients_method)</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">File "/Applications/phenix-1.20.1-4487/modules/cctbx_project/mmtbx/refinement/real_space/weight.py", line 87, in __init__</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">rms_angles_limit = rms_angles_limit)</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">File "/Applications/phenix-1.20.1-4487/modules/cctbx_project/mmtbx/refinement/real_space/individual_sites.py", line 368, in refine</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">rms_angles_limit = rms_angles_limit)</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">File "/Applications/phenix-1.20.1-4487/modules/cctbx_project/mmtbx/refinement/real_space/individual_sites.py", line 235, in __init__</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">weight
</span><span class="apple-converted-space"> </span><span class="s1">= weight)</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">File "/Applications/phenix-1.20.1-4487/modules/cctbx_project/mmtbx/refinement/real_space/individual_sites.py", line 112, in refine</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">states_collector</span><span class="apple-converted-space">
</span><span class="s1">= self.states_accumulator)</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">File "/Applications/phenix-1.20.1-4487/modules/cctbx_project/cctbx/maptbx/real_space_refinement_simple.py", line 174, in __init__</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">exception_handling_params=lbfgs_exception_handling_params)</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">File "/Applications/phenix-1.20.1-4487/modules/cctbx_project/scitbx/lbfgs/__init__.py", line 278, in run</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">line_search)</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">File "/Applications/phenix-1.20.1-4487/modules/cctbx_project/scitbx/lbfgs/__init__.py", line 131, in run_c_plus_plus</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">f, g = target_evaluator.compute_functional_and_gradients()</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">File "/Applications/phenix-1.20.1-4487/modules/cctbx_project/cctbx/maptbx/real_space_refinement_simple.py", line 245, in compute_functional_and_gradients</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">compute_gradients=True)</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">File "/Applications/phenix-1.20.1-4487/modules/cctbx_project/cctbx/geometry_restraints/manager.py", line 1479, in energies_sites</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">flags=flags, sites_cart=sites_cart, site_labels=site_labels)</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">File "/Applications/phenix-1.20.1-4487/modules/cctbx_project/cctbx/geometry_restraints/manager.py", line 1381, in pair_proxies</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">check_bonded_distance_cutoff(sites_frac=sites_frac)</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">File "/Applications/phenix-1.20.1-4487/modules/cctbx_project/cctbx/geometry_restraints/manager.py", line 1262, in check_bonded_distance_cutoff</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">raise RuntimeError(msg)</span><o:p></o:p></p>
<p class="p1"><span class="s1">RuntimeError: Bond distance > max_reasonable_bond_distance: 58.8204 > 50:</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 19 - 25:</span><span class="apple-converted-space">
</span><span class="s1">20.675</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 21 - 22:
</span><span class="apple-converted-space"> </span><span class="s1">4.594</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 21 - 23:</span><span class="apple-converted-space">
</span><span class="s1">14.720</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 22 - 24:</span><span class="apple-converted-space">
</span><span class="s1">27.218</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 25 - 26:</span><span class="apple-converted-space">
</span><span class="s1">15.535</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 25 - 138:</span><span class="apple-converted-space">
</span><span class="s1">20.583</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 26 - 27:</span><span class="apple-converted-space">
</span><span class="s1">10.976</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 26 - 29:
</span><span class="apple-converted-space"> </span><span class="s1">9.260</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 27 - 28:
</span><span class="apple-converted-space"> </span><span class="s1">6.472</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 27 - 34:</span><span class="apple-converted-space">
</span><span class="s1">28.251</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 28 - 135:</span><span class="apple-converted-space">
</span><span class="s1">26.553</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 29 - 30:</span><span class="apple-converted-space">
</span><span class="s1">30.275</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 30 - 31:</span><span class="apple-converted-space">
</span><span class="s1">45.594</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 31 - 32:</span><span class="apple-converted-space">
</span><span class="s1">42.003</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 32 - 33:</span><span class="apple-converted-space">
</span><span class="s1">58.820</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 34 - 35:</span><span class="apple-converted-space">
</span><span class="s1">15.118</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 34 - 40:</span><span class="apple-converted-space">
</span><span class="s1">32.473</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 35 - 36:</span><span class="apple-converted-space">
</span><span class="s1">10.126</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 35 - 38:</span><span class="apple-converted-space">
</span><span class="s1">33.272</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 36 - 37:</span><span class="apple-converted-space">
</span><span class="s1">36.153</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 36 - 41:</span><span class="apple-converted-space">
</span><span class="s1">14.653</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 38 - 39:</span><span class="apple-converted-space">
</span><span class="s1">31.110</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 39 - 40:</span><span class="apple-converted-space">
</span><span class="s1">31.467</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 41 - 42:</span><span class="apple-converted-space">
</span><span class="s1">36.418</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 42 - 43:</span><span class="apple-converted-space">
</span><span class="s1">13.145</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 43 - 44:
</span><span class="apple-converted-space"> </span><span class="s1">8.206</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 43 - 45:</span><span class="apple-converted-space">
</span><span class="s1">40.869</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 45 - 46:</span><span class="apple-converted-space">
</span><span class="s1">12.390</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 46 - 47:</span><span class="apple-converted-space">
</span><span class="s1">25.848</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 46 - 49:</span><span class="apple-converted-space">
</span><span class="s1">16.457</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 47 - 48:</span><span class="apple-converted-space">
</span><span class="s1">15.264</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 47 - 53:</span><span class="apple-converted-space">
</span><span class="s1">38.374</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 49 - 50:</span><span class="apple-converted-space">
</span><span class="s1">27.548</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 50 - 51:</span><span class="apple-converted-space">
</span><span class="s1">46.020</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 50 - 52:</span><span class="apple-converted-space">
</span><span class="s1">31.107</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 53 - 54:</span><span class="apple-converted-space">
</span><span class="s1">25.030</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 54 - 55:</span><span class="apple-converted-space">
</span><span class="s1">33.266</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 55 - 56:</span><span class="apple-converted-space">
</span><span class="s1">15.731</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 55 - 57:</span><span class="apple-converted-space">
</span><span class="s1">17.553</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 57 - 58:
</span><span class="apple-converted-space"> </span><span class="s1">8.147</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 58 - 59:</span><span class="apple-converted-space">
</span><span class="s1">15.533</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 58 - 61:
</span><span class="apple-converted-space"> </span><span class="s1">3.968</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 59 - 60:</span><span class="apple-converted-space">
</span><span class="s1">32.012</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 59 - 66:</span><span class="apple-converted-space">
</span><span class="s1">13.102</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 60 - 143:</span><span class="apple-converted-space">
</span><span class="s1">27.836</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 61 - 62:</span><span class="apple-converted-space">
</span><span class="s1">21.904</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 62 - 63:</span><span class="apple-converted-space">
</span><span class="s1">22.068</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 63 - 64:</span><span class="apple-converted-space">
</span><span class="s1">40.044</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 64 - 65:</span><span class="apple-converted-space">
</span><span class="s1">14.241</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 66 - 67:</span><span class="apple-converted-space">
</span><span class="s1">13.162</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 67 - 68:</span><span class="apple-converted-space">
</span><span class="s1">14.727</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 67 - 70:</span><span class="apple-converted-space">
</span><span class="s1">18.482</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 68 - 69:
</span><span class="apple-converted-space"> </span><span class="s1">7.119</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 68 - 74:</span><span class="apple-converted-space">
</span><span class="s1">16.874</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 70 - 71:</span><span class="apple-converted-space">
</span><span class="s1">23.617</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 70 - 72:</span><span class="apple-converted-space">
</span><span class="s1">26.751</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 71 - 73:</span><span class="apple-converted-space">
</span><span class="s1">31.237</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 74 - 75:</span><span class="apple-converted-space">
</span><span class="s1">24.016</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 74 - 146:</span><span class="apple-converted-space">
</span><span class="s1">23.850</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 75 - 76:</span><span class="apple-converted-space">
</span><span class="s1">10.199</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 75 - 78:</span><span class="apple-converted-space">
</span><span class="s1">26.004</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 76 - 77:</span><span class="apple-converted-space">
</span><span class="s1">12.111</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 76 - 81:</span><span class="apple-converted-space">
</span><span class="s1">13.195</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 77 - 157:</span><span class="apple-converted-space">
</span><span class="s1">10.604</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 78 - 79:</span><span class="apple-converted-space">
</span><span class="s1">24.115</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 78 - 80:</span><span class="apple-converted-space">
</span><span class="s1">26.622</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 81 - 82:
</span><span class="apple-converted-space"> </span><span class="s1">9.528</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 82 - 83:</span><span class="apple-converted-space">
</span><span class="s1">10.254</span><o:p></o:p></p>
<p class="p1"><span class="apple-converted-space"> </span><span class="s1">distance: 82 - 85:
</span><span class="apple-converted-space"> </span><span class="s1">9.660</span><o:p></o:p></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
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