Python-based Hierarchical ENvironment for Integrated Xtallography

PHENIX nightly build distribution

These installers are built automatically using the current source code and are automatically tested. We do not release installers that have known major problems, so these builds should be suitable for most purposes. Official releases and builds deemed to be "stable" are noted as such and highlighted in bold type.

If you do use the nightly builds, we recommend updating frequently; once a build disappears from the list here, it can be assumed to be obsolete.

If you encounter errors when using any of these builds, please update to the most recent build before sending a bug report. (It is generally a good idea to update frequently anyway, since the code changes rapidly.)

Note: Phenix installers are available for 64-bit Windows systems (Windows 7 or newer). Some programs or features are not available because of limitations of the Windows platform; please read the platform support notes for details. We appreciate any feedback about bugs or inconsistencies.

You will need proper authentication to download the installer; see the main download page for details.

VersionDateStatus LogsInfo
1.19rc6-40612020-11-20successful ci, mac-intel-osx-x86_64, intel-windows-x86_64, intel-linux-2.6-x86_64-centos6 docs; changelog
1.19rc5-40472020-11-06successful ci, intel-windows-x86_64, intel-linux-2.6-x86_64-centos6, mac-intel-osx-x86_64 docs; changelog
1.19rc4-40352020-10-25successful ci, intel-linux-2.6-x86_64-centos6, intel-windows-x86_64, mac-intel-osx-x86_64 docs; changelog
1.19rc3-40282020-10-18successful ci, mac-intel-osx-x86_64, intel-windows-x86_64, intel-linux-2.6-x86_64-centos6 docs; changelog
1.19rc3-40242020-10-14successful ci, intel-linux-2.6-x86_64-centos6, mac-intel-osx-x86_64, intel-windows-x86_64 docs; changelog
1.19rc2-40222020-10-12successful ci, mac-intel-osx-x86_64, intel-windows-x86_64, intel-linux-2.6-x86_64-centos6 docs; changelog
1.19rc1-40162020-10-06successful ci, intel-windows-x86_64, mac-intel-osx-x86_64, intel-linux-2.6-x86_64-centos6 docs; changelog
1.18.2-38742020-05-17successful ci, intel-windows-x86_64, intel-linux-2.6-x86_64-centos6, mac-intel-osx-x86_64 docs; changelog
User notes for 1.18.2-3874:

1.18.2 Changes

  • Fix weighting for iron sulfur clusters

1.18.1 Changes

  • General bug fixes
1.18 Changes
  • Amber
    • Automatic creation of Amber files in phenix.refine GUI
    • Added AmberPrep GUI
  • Restraints
    • Engh & Huber restraints (2001) for cis-peptides now implemented
    • Restraints added for FeS
    • Metal coordination library is default to Zn+2 and FeS clusters
  • Rama-Z: New global Ramachandran score for identifying protein structures with unlikely stereochemistry in CLI (phenix.rama_z, mmtbx.rama_z) and GUI (validation reports).
  • Density modification for cryo-EM
    • Includes model-based density modification with automatic model generation
    • Optimized defaults and additional documentation
  • Real-space refinement
    • Hydrogen atoms no longer included in map target function, which improves fit.
    • Add NQH flip option (enabled by default)
  • Other
    • New tool for ordered solvent picking in cryo-EM maps (phenix.douse)
    • New map and model superposition tool (phenix.match_maps)
    • New FindProgram toll to find any Phenix program with a text search
    • Project details now has a button for opening the README file for tutorials

1.17.1-36602019-10-16successful ci, intel-windows-x86_64, intel-linux-2.6-x86_64-centos6, mac-intel-osx-x86_64 Official 1.17.1 release; docs; changelog
User notes for 1.17.1-3660:

1.17.1 Changes

  • Fix bug on Windows where Xtriage results would fail to display
  • Other bug fixes
1.17 Changes
  • Improved handling of SHELX data in phenix.reflection_file_converter
  • eLBOW can output files for Amber
  • eLBOW supports QM package Orca
  • dials.image_viewer is used for viewing diffraction images
  • Updated map smoothing
  • Fix inconsistency in clashscore values in phenix.validation_cryoem when hydrogens are in the model

1.16-35492019-06-27successful ci, intel-linux-2.6-x86_64-centos6, mac-intel-osx-x86_64, intel-windows-x86_64 Official 1.16 release; docs; changelog
User notes for 1.16-3549:

1.16 Changes

  • New GUI for mmtbx.prepare_pdb_deposition to make mmCIF files for deposition into the PDB
  • New tool (CLI and GUI) for getting a validation report from the PDB (phenix.get_pdb_validation_report)
  • Added sequence checking to Comprehensive Validation for Cryo-EM
  • Amber functionality is available by default

1.15.2-34722019-04-11successful ci, intel-windows-x86_64, intel-linux-2.6-x86_64-centos6, mac-intel-osx-x86_64 Official 1.15.2 release; docs; changelog
User notes for 1.15.2-3472:

1.15.2 Changes

  • Fix phenix.rosetta_refine issue
  • Fix PDB/CIF conversion in GUI

1.15.1 Changes

  • Improved phenix.map_to_model behavior

New and improved tools

  • New algorithm for phenix.map_to_model is faster and builds longer chains
  • phenix.trace_and_build can build protein into maps at resolutions as low as 4.5 A
  • phenix.fix_insertions_deletions can build models in places where the map is poor
  • phenix.refine_ca_model for optimizing C-alpha only models
  • phenix.comparama for generating Kleywegt-like plots that show how residues moved in the Rakmachandran plots before and after refinement
  • eLBOW can find unique instances of a ligand from the PDB and optionally create Polder OMIT maps
  • Updated structural library for phenix.structure_search
  • Updated ligand library for phenix.ligand_identification
  • Improved reporting of cis-peptides for residues with altloc atoms
Other improvements
  • Updated mmCIF support (stuct_conn loop, ligand restraints, sequence)
  • phenix.refine, phenix.real_space_refine, and phenix.pdbtools will also output models in mmCIF format by default
  • Dependencies are now based on conda packages, which will be more compatible with new operating systems and will improve consistency across all platforms (macOS, linux, Windows)
  • Bug fixes

1.14-32602018-09-11successful ci, mac-intel-osx-x86_64, intel-windows-x86_64, intel-windows, intel-linux-2.6-x86_64-centos6, intel-linux-2.6-centos5, intel-linux-2.6-x86_64-centos5 Official 1.14 release; docs; changelog
User notes for 1.14-3260:

Reorganization and addition of cryo-EM tools

  • phenix.mtriage - assess map and model quality
  • phenix.auto_sharpen - map sharpening
  • phenix.map_symmetry - identify symmetry in maps
  • phenix.map_box - cut out unique parts of maps
  • phenix.combine_focused_maps - combine different maps
  • phenix.dock_in_map - automatically place a model into a map
  • phenix.map_to_model - automatically build model into a map
  • phenix.sequence_from_map - identify sequence from a map
  • phenix.real_space_refine - improved refining to models
  • phenix.validation_cryoem - separate tool for comprehensive validation of models and maps
  • Bug fixes
  • Improved data information content functionality
  • Better support for metals and metal clusters
  • Added support for QM package, Orca
Other improvements
  • Better performance
    • NCS search
    • Generating secondary structure restraints
    • Clashscore calculation
  • phenix.ligand_identification - option to generate ligand library based on sequence and structural homologs of input

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