Python-based Hierarchical ENvironment for Integrated Xtallography

PHENIX nightly build distribution

These installers are built automatically using the current source code and are automatically tested. We do not release installers that have known major problems, so these builds should be suitable for most purposes. Official releases and builds deemed to be "stable" are noted as such and highlighted in bold type.

If you do use the nightly builds, we recommend updating frequently; once a build disappears from the list here, it can be assumed to be obsolete.

If you encounter errors when using any of these builds, please update to the most recent build before sending a bug report. (It is generally a good idea to update frequently anyway, since the code changes rapidly.)

Note: Phenix installers are available for 64-bit Windows systems (Windows 7 or newer). Some programs or features are not available because of limitations of the Windows platform; please read the platform support notes for details. We appreciate any feedback about bugs or inconsistencies.

You will need proper authentication to download the installer; see the main download page for details.

VersionDateStatus LogsInfo
1.17rc4-36262019-09-12successful intel-windows-x86_64, ci, mac-intel-osx-x86_64, intel-linux-2.6-x86_64-centos6 docs; changelog
1.17rc2-36192019-09-05successful ci, intel-windows-x86_64, mac-intel-osx-x86_64, intel-linux-2.6-x86_64-centos6 docs; changelog
User notes for 1.17rc2-3619: Release Candidate 3, even though it's labeled rc2
1.17rc2-36122019-08-29successful ci, mac-intel-osx-x86_64, intel-linux-2.6-x86_64-centos6, intel-windows-x86_64 docs; changelog
1.17rc1-36052019-08-22successful ci, intel-linux-2.6-x86_64-centos6, mac-intel-osx-x86_64, intel-windows-x86_64 docs; changelog
1.16-35492019-06-27successful ci, intel-linux-2.6-x86_64-centos6, mac-intel-osx-x86_64, intel-windows-x86_64 Official 1.16 release; docs; changelog
User notes for 1.16-3549:

1.16 Changes

  • New GUI for mmtbx.prepare_pdb_deposition to make mmCIF files for deposition into the PDB
  • New tool (CLI and GUI) for getting a validation report from the PDB (phenix.get_pdb_validation_report)
  • Added sequence checking to Comprehensive Validation for Cryo-EM
  • Amber functionality is available by default

1.15.2-34722019-04-11successful ci, intel-windows-x86_64, intel-linux-2.6-x86_64-centos6, mac-intel-osx-x86_64 Official 1.15.2 release; docs; changelog
User notes for 1.15.2-3472:

1.15.2 Changes

  • Fix phenix.rosetta_refine issue
  • Fix PDB/CIF conversion in GUI

1.15.1 Changes

  • Improved phenix.map_to_model behavior

New and improved tools

  • New algorithm for phenix.map_to_model is faster and builds longer chains
  • phenix.trace_and_build can build protein into maps at resolutions as low as 4.5 A
  • phenix.fix_insertions_deletions can build models in places where the map is poor
  • phenix.refine_ca_model for optimizing C-alpha only models
  • phenix.comparama for generating Kleywegt-like plots that show how residues moved in the Rakmachandran plots before and after refinement
  • eLBOW can find unique instances of a ligand from the PDB and optionally create Polder OMIT maps
  • Updated structural library for phenix.structure_search
  • Updated ligand library for phenix.ligand_identification
  • Improved reporting of cis-peptides for residues with altloc atoms
Other improvements
  • Updated mmCIF support (stuct_conn loop, ligand restraints, sequence)
  • phenix.refine, phenix.real_space_refine, and phenix.pdbtools will also output models in mmCIF format by default
  • Dependencies are now based on conda packages, which will be more compatible with new operating systems and will improve consistency across all platforms (macOS, linux, Windows)
  • Bug fixes

1.14-32602018-09-11successful ci, mac-intel-osx-x86_64, intel-windows-x86_64, intel-windows, intel-linux-2.6-x86_64-centos6, intel-linux-2.6-centos5, intel-linux-2.6-x86_64-centos5 Official 1.14 release; docs; changelog
User notes for 1.14-3260:

Reorganization and addition of cryo-EM tools

  • phenix.mtriage - assess map and model quality
  • phenix.auto_sharpen - map sharpening
  • phenix.map_symmetry - identify symmetry in maps
  • phenix.map_box - cut out unique parts of maps
  • phenix.combine_focused_maps - combine different maps
  • phenix.dock_in_map - automatically place a model into a map
  • phenix.map_to_model - automatically build model into a map
  • phenix.sequence_from_map - identify sequence from a map
  • phenix.real_space_refine - improved refining to models
  • phenix.validation_cryoem - separate tool for comprehensive validation of models and maps
  • Bug fixes
  • Improved data information content functionality
  • Better support for metals and metal clusters
  • Added support for QM package, Orca
Other improvements
  • Better performance
    • NCS search
    • Generating secondary structure restraints
    • Clashscore calculation
  • phenix.ligand_identification - option to generate ligand library based on sequence and structural homologs of input
1.13-29982017-12-23successful ci, intel-windows, intel-windows-x86_64, intel-linux-2.6-centos5, mac-intel-osx-x86_64, intel-linux-2.6-x86_64-centos6, intel-linux-2.6-x86_64-centos5 Official 1.13 release; docs; changelog
User notes for 1.13-2998:


  • phenix.map_to_model - better symmetry support and improved runtime efficiency
  • phenix.structure_search - structural library and internal support for mmCIF
  • phenix.ligand_identification - limit ligand size for search
  • Phaser 2.8.1 - various bug fixes
  • Structure Comparison - more/improved validation information (ligands, waters, cis/trans peptides, HIS protonation)
  • GUI - automatic validation after phenix.real_space_refine; visual improvements in validation
  • Internal bug fixes and performance improvements
1.12-28292017-07-07successful ci, intel-windows-x86_64, mac-intel-osx-x86_64, intel-windows, intel-linux-2.6-x86_64-centos5, intel-linux-2.6-x86_64-centos6, intel-linux-2.6-centos5 Official 1.12 Release; docs; changelog
User notes for 1.12-2829:

New Tools: phenix.secondary_structure_validation, Structure Comparison, phenix.mtriage, phenix.real_space_diff_map

Improvements: better sharpening algorithms in phenix.auto_sharpen; better iterative map improvement in phenix.map_to_model; individual mapping in phenix.map_to_object; better outlier rejection in ssm-rmsd calculation in phenix.find_alt_orig_sym_mate; Secondary structure restraints use angles for restraining hydrogen bonds; User-defined box in phenix.polder in addition to atom selection; various improvements to phenix.real_space_refine; can have different restraints for different copies of the same ligand in the same model; better control of peptide planes and omega angles; faster calculation of clashscore; improved handling of cis-peptides in ramalyze; various bug fixes and updated dependencies

GUI: new interfaces for phenix.mtriage, phenix.map_box, phenix.auto_sharpen, phenix.map_to_model, phenix.ncs_average, phenix.sculpt_ensemble

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