[phenixbb] Postdoctoral position in method development (York Structural Biology Laboratory)

[Jon Agirre]

Dear all,

Applications are invited for a Postdoctoral Research Associate position,
funded by the Royal Society, for up to 30 months to work with Dr Jon Agirre in
the Department of Chemistry. The successful applicant will join a vibrant
team of researchers at the heart of the world-leading York Structural
Biology Laboratory (YSBL). The work of the laboratory over the years has
included the delivery of world-leading methods and experimental
discoveries, training and nurturing hundreds of outstanding scientists in
the process.

Role
The AlphaFold software for protein model prediction has revolutionised
workflows in structural biology. However, while high-accuracy models are
now available for most human proteins of medical relevance, up to 50% of
those proteins are expected to be glycosylated – a modification whose
structure AlphaFold does not predict. Protein glycosylation is greatly
important, with implications for protein folding and molecular recognition
including, as evidenced by the spike glycoprotein of SARS-CoV-2, viral
infection. In collaboration with other scientists, we have extended the
Privateer software to interactively build missing glycosylation onto
precalculated AlphaFold models. In parallel, we have developed analyses
that allow us to get a clear picture of glycans and their interactions,
including H-bonds and XH-Pi interactions. We expect that these methods will
enable us to, based on existing glycobiological knowledge, extend the
Privateer software to automatically complete AlphaFold models with crucial
missing glycosylation components.

We are seeking a person with an interest in both biology and coding, who
can collaborate with others in a very diverse team with a mission to
further our knowledge of glycobiology and seize the opportunities presented
by a deeper understanding of it.

Main duties and responsibilities
To develop and extend the Privateer software to complete AlphaFold models
with the missing glycan components.
To further our existing collaborations with CCP4, CCP-EM, PDB-REDO, the
Protein Data Bank and the AlphaFold Protein Structure Database.

Department
The Department of Chemistry is one of the largest and most successful
departments at York and we are renowned internationally for our research.
As a department, we strive to provide a working environment that allows all
staff and students to contribute fully, to flourish, and to excel. We are
proud of our Athena Swan Gold Award. The Department of Chemistry values all
employees for the qualities and skills they bring to the workplace and aims
to be a diverse and egalitarian community in which all can thrive.

For informal enquiries: please contact Dr Jon Agirre, jon.agirre at york.ac.uk
To apply: https://jobs.york.ac.uk/vacancy/research-associate-529961.html
Deadline for applications: 20 August 2023.

Many thanks for making it this far in the advert!

With best wishes,
Jon
-- 
Dr Jon Agirre
Royal Society University Research Fellow (assistant professor)
CCP4 WG2 co-chair | instruct-ERIC representative @ 3D-Bioinfo SC (Elixir)
York Structural Biology Laboratory, Department of Chemistry
University of York, Heslington, YO10 5DD, York, UK
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