On Mar 27, 2013, at 12:32 PM, Anastassis Perrakis wrote:

These said, I am rather easily irritated these days, so I will not comment on the irritable character of the email. ... we will soon start calling disordered loops positionally challenged polypeptide segments (*).

You might want to embrace the power of positive thinking. Where you see "positionally challenged", an optimist would see "entropically gifted". James