The Phenix National Resource

The Phenix software, cctbx library, and associated activities such as outreach and training are a national resource funded by a NIGMS R24 grant.

What is the Phenix Resource?

Phenix is a software suite that uses reduced data from X-ray diffraction, electron diffraction, neutron diffraction or cryo-EM 3D reconstructions to determine macromolecular structures. It provides tools to address the unique properties of the experimental data, while maximally exploiting the commonalities in computational steps. Emphasis is put on the automation of procedures to avoid burdening the user with repetitive, time-consuming and potentially error-prone manual tasks. Another important feature is the user-friendly design, which makes the program accessible to novice users while also keeping it flexible for experts.

Goals of the Phenix Resource

The primary goal of the Phenix Resource is to provide the research community with high quality software in two forms: 1) the Phenix package, which is mainly used by experimentalists to analyze their data; 2) the cctbx library, which is used by others to develop new programs. For example, the cctbx, which forms the basis of the DIALS software developed by researchers at LBL and Diamond Light Source, is also an essential component of the CCP4 software package, and is the platform for the development of the Olex2 program for small molecule crystallography.

Activities of the Phenix Resource

The Phenix Resource has the following core activities that enable the Phenix team to provide the research community with high quality software:

  • Code maintenance
  • Code optimization
  • Maintenance of data resources and libraries
  • Usability improvements
  • Dissemination
  • Outreach
  • Training
  • User support

The activities that constitute the Phenix Resource and how information flows to the research community and other software developers. Activities funded by the R24 grant are shown in yellow. * denotes activities that have some contributions from the broader Phenix developer team..

Organization

Organization of the Phenix Resource. Leads for the main activities are indicated; staff make contributions to multiple activities.
Paul Adams

Resource Director and Principal Investigator

Dorothee Liebschner

Deputy Director, lead for Outreach and Training

Billy Poon

Lead for Program Integration and for Dissemination

Oleg Sobolev

Lead for Program Maintenance & Optimization